Roma will look to Paulo Dybala and Donyell Malen in a big home game against Inter, while the Nerazzurri will look to Lautaro Martinez and Marcus Thuram.

It kicks off at 18:00 CET [17:00 BST] at the Stadio Olimpico in Rome.

TURIN, ITALY – SEPTEMBER 14: Donyell Malen of AS Roma celebrates scoring his team’s first goal with teammate Mario Hermoso during the Serie A match between Torino FC and AS Roma at Stadio Olimpico Grande Torino on September 14, 2026 in Turin, Italy. (Photo by Valerio Pennicino/Getty Images)

Inter and Roma are the only two Serie A teams to have collected 12 points in the opening four games of the season, winning all their league matches so far.

Inter have the best attack with 13 goals, one more than Roma, while the Giallorossi have the least-beaten defence with just one goal conceded, compared with Inter’s six.

MADRID, SPAIN – SEPTEMBER 08: Lautaro Martinez of Internazionale looks on during the UEFA Champions League 2026/27 League Phase MD1 match between Real Madrid C.F. and FC Internazionale Milano at Estadio Santiago Bernabeu on September 08, 2026 in Madrid, Spain. (Photo by Angel Martinez/Getty Images)

The Giallorossi can rely on a full squad, while Inter have travelled to the Olimpico without Djed Spence, John Stones and Hakan Calhanoglu.

According to several sources, Piotr Zielinski will replace Calhanoglu in the middle of the park for Inter, while Curtis Jones is favourite over Petar Sucic.