Roma without Donyell Malen and Paulo Dybala give Santiago Castro and Rodrigo Mora a chance, as Genoa coach Daniele De Rossi returns to the Stadio Olimpico with Stephan El Shaarawy.

It kicks off at the Stadio Olimpico at 19.45 UK time (20.45 CEST).

You can follow all the build-up and action as it happens from this game and Bologna-Inter on the Liveblog.

ROME, ITALY – OCTOBER 14: Antonio Rudiger of Real Madrid scores his team’s fourth goal during the UEFA Champions League 2026/27 League Phase MD2 match between AS Roma and Real Madrid C.F. at Stadio Olimpico on October 14, 2026 in Rome, Italy. (Photo by Paolo Bruno/Getty Images)

The Giallorossi are still stunned by the 4-3 Champions League defeat to Real Madrid on Wednesday, a game they had been leading 3-1 until conceding three almost identical late goals from corner kicks.

To make matters worse, Paulo Dybala and Manu Koné both sustained muscular injuries in that game and are therefore ruled out, with Mile Svilar and Bryan Cristante already on the treatment table.

Malen is suspended after his red card in the 0-0 draw with Como, so Castro has to lead the attack with support from Mora and Matias Soulé, while Niccolò Pisilli steps into midfield.

Gianluca Mancini isn’t fully fit either and Nahuel Molina rested, with Pierluigi Gollini facing his former club.

From a tactical formation and squad depth perspective, "Alineaciones de la Serie A: Roma vs.Génova" carries substantial tournament implications for international seeding and domestic campaign momentum. Coaching staffs are heavily weighing high-pressing efficiency (PPDA), defensive transition pace, and fixture fatigue management.

Tactical analysts monitoring Champions League metrics emphasize that squad adaptability and set-piece execution will likely dictate outcomes in high-leverage knockout environments. Real-time match telemetry and tracking data continue to inform managerial decision-making.

Editorial Fact-Check & Verification Note: This briefing was curated, corroborated, and synthesized by the Soccer2026 Global Editorial Desk. Readers following "Alineaciones de la Serie A: Roma vs.Génova" are encouraged to review the full primary source coverage linked below for complete historical context, direct quotes, and official statements.