Diego Moreira is set to start for Milan in an away game at Sassuolo, who will look to Sebastiano Esposito and Domenico Berardi.

It kicks off at 18:00 CET [17:00 BST] at the Mapei Stadium in Reggio Emilia.

ITALY – SEPTEMBER 20: Ruben Amorim, Manager of AC Milan, looks on before the Serie A match between AC Milan and US Lecce at Stadio Giuseppe Meazza on September 20, 2026 in Italy. (Photo by Marco Luzzani/Getty Images)

According to several sources, Milan coach Ruben Amorim will switch to a four-man defence, as he did against Lecce before the break, using Mario Gila at right-back and Diego Moreira on the left flank.

Christian Pulisic will start as an attacking midfielder, with Gonçalo Ramos as the sole striker.

Luka Modric might rest, making room for Yunus Musah in central midfield.

ITALY – SEPTEMBER 16: Fredrik Aursnes of SL Benfica is pressured by Yunus Musah of AC Milan during the UEFA Europa League 2026/27 League Phase MD1 match between AC Milan and SL Benfica at Stadio San Siro on September 16, 2026 in Italy. (Photo by Marco Luzzani/Getty Images)

Alexis Saelemaekers and second-choice keeper Pietro Terracciano are unavailable for the Rossoneri.

From a tactical formation and squad depth perspective, "Serie A: Sassuolo vs. Milan – probable line-ups, where to watch on TV" carries substantial tournament implications for international seeding and domestic campaign momentum. Coaching staffs are heavily weighing high-pressing efficiency (PPDA), defensive transition pace, and fixture fatigue management.

Tactical analysts monitoring Champions League metrics emphasize that squad adaptability and set-piece execution will likely dictate outcomes in high-leverage knockout environments. Real-time match telemetry and tracking data continue to inform managerial decision-making.

Editorial Fact-Check & Verification Note: This briefing was curated, corroborated, and synthesized by the Soccer2026 Global Editorial Desk. Readers following "Serie A: Sassuolo vs. Milan – probable line-ups, where to watch on TV" are encouraged to review the full primary source coverage linked below for complete historical context, direct quotes, and official statements.