Lorenzo Lucca and Sam Beukema are set to start for Napoli as Davide Nicola takes charge of Venezia for the first time.

It kicks off at 15:00 CET [14:00 BST] at the Stadio Pierluigi Penzo in Venice.

Venezia are bottom of Serie A and the only side without a point after six straight defeats. Monday’s 3-1 loss at Atalanta cost Giovanni Stroppa his job. Massimiliano Allegri’s Napoli beat Frosinone in their last league game, but arrive after a 3-1 Champions League defeat at Villarreal on Tuesday. That left them with four losses from their first eight competitive matches, their worst start in 17 year s.

NAPLES, ITALY – OCTOBER 10: Massimiliano Allegri, Manager of SSC Napoli, reacts during the Serie A match between SSC Napoli and Frosinone Calcio at Stadio Diego Armando Maradona on October 10, 2026 in Naples, Italy. (Photo by Francesco Pecoraro/Getty Images)

Napoli are without Alessandro Buongiorno, Costantino Favasuli and Antonio Vergara, while David Neres misses out with a muscle problem. Frank Anguissa, Mathías Olivera and Alisson Santos are back in training but expected to start on the bench, and Kevin De Bruyne is set to be rested.

According to Sky , Allegri will start Lucca ahead of Rasmus Hojlund. Beukema is in line for his season debut ahead of Luca Marianucci, and Benoît Badiashile is favoured over Rafa Marín. Corriere dello Sport expects Billy Gilmour and Stanislav Lobotka to form a double pivot, with Scott McTominay and Giovane behind Lucca.

Tuttosport, however, has McTominay in midfield alongside Lobotka, with Matteo Politano and Noa Lang supporting Lucca.

Nicola is expected to stick with a 3-5-2 and the strike partnership of John Yeboah and Akor Adams. Gianluca Busio is still out, while Armel Bella-Kotchap’s fitness will be assessed.

From a tactical formation and squad depth perspective, "Serie A | Venezia vs. Napoli: Probable line-ups and where to watch on TV" carries substantial tournament implications for international seeding and domestic campaign momentum. Coaching staffs are heavily weighing high-pressing efficiency (PPDA), defensive transition pace, and fixture fatigue management.

Tactical analysts monitoring Champions League metrics emphasize that squad adaptability and set-piece execution will likely dictate outcomes in high-leverage knockout environments. Real-time match telemetry and tracking data continue to inform managerial decision-making.

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